How long to cook chicken breast at 375°F

A boneless, skinless chicken breast at 375°F takes 22 to 28 minutes to reach a safe 165°F internal temperature. Bone-in, skin-on breasts run 35 to 45 minutes. The exact number depends on weight, starting temperature, and how crowded the pan is.

The number that actually matters

USDA pulls no punches: chicken is done at 165°F (74°C) measured at the thickest part of the breast, not by time, not by color, not by juice clarity. A meat thermometer is the only reliable test. Pull the breast at 160°F and let carryover cooking finish the job — temperature will rise 5–8°F while it rests.

Cook time by weight at 375°F

Cut	6 oz	8 oz	10 oz	12 oz
Boneless, skinless	20 min	24 min	27 min	30 min
Bone-in, skin-on	32 min	38 min	42 min	48 min

Add 3–5 minutes if you're cooking straight from the fridge — a cold breast in a hot oven cooks unevenly. Take it out 20 minutes before cooking and the timing tightens up.

Scaling for a crowd

Four breasts in a pan don't cook in 4× the time. They cook in roughly the same time, plus 2–3 minutes for the extra thermal mass. If you're batch-cooking for the week, use the Recipe Scaler to scale the rub and brine, not the timing.

For Thanksgiving-size birds, switch to the Turkey Cooking Time Calculator — different cut, different rules.

Bottom line

Boneless breasts at 375°F: roughly 22–28 minutes. Bone-in: roughly 35–45. The thermometer is the answer; the clock is the estimate.